Premature ejaculation is defined as the occurrence of ejaculation prior to the wishes of both sexual partners. There is thus no specific or precise duration for reaching a climax as this is quite variable and depends on many factors specific to the individuals engaging in sexual activity. It is a psychological problem and does not represent any known organic disease involving the male reproductive tract or any known lesions in the brain or nervous system. The optimal medical treatment for PE has not been established and the U.S. FDA has not approved any drug for its treatment but many studies have shown that a group of drugs called selective serotonin reuptake inhibitors (SSRIs) and drugs with SSRI-like side effects are safe and effective to treat this condition. Dapoxetine is a novel, fast-acting serotonin reuptake inhibitor which under FDA review for the treatment of premature ejaculation. Recent phase 3 clinical trials in patients with premature ejaculation have shown it to be effective in improving the time to ejaculation without any major adverse events, except nausea.

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